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인하대학교, University of Southern California

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Coord. Chem. Rev., Available online 26 November 2023 | https://doi.org/10.1016/j.ccr.2023.215567 Photoactivable liposomes for controlled delivery: Recent progress and design considerations

Seoyoon Song ^a,b,1, Deborah Lee ^a,b,1, Lucia C. Dalle Ore ^b, Sungjun Kwak ^a, Lifeng Kang ^c, Hyung Kyo Kim ^d, Noah Malmstadt^b, Sun Min Kim ^a,e,f, Tae-Joon Jeon ^a,e,g

^aDepartment of Biological Sciences and Bioengineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea

^bMork Family Department of Chemical Engineering and Materials Science, 925 Bloom Walk, Los Angeles, CA 90089-1211, USA

^cSchool of Pharmacy, Faculty of Medicine and Health, University of Sydney, Pharmacy and Bank Building A15, NSW 2006 Australia

^dDepartment of Materials Research Center, Genpeau Corporation, Incheon 21990, Republic of Korea

^eBiohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea

^fDepartment of Mechanical Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea

^gDepartment of Biological Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea

¹These authors contributed equally to this work.

Corresponding authors : Sun Min Kim, Tae-Joon Jeon

Abstract

Recent strides in drug delivery have aimed at precise control over therapeutic agent release and targeting. Liposomes, lipid-based vesicles, have stood out for their capacity to encapsulate diverse agents. While their structural features offer biocompatibility and stability, the inability to provide on-demand drug release limits their efficacy. Addressing these limitations, photoactivable liposomes, leveraging light as a trigger, offer a compelling solution. This strategy surpasses established controlled systems, providing spatiotemporal precision and non-invasive external triggering. Furthermore, the versatility of photoactivation, achieved through the manipulation of light-responsive components, enables meticulous control over release kinetics. While extant reviews predominantly concentrate on release strategies and materials, this paper takes a novel approach by spotlighting recent advancements in categorized photoactivable liposomes. Moreover, drawing from contemporary illustrations, the article accentuates design considerations that encompass physicochemical properties and light-related constituents. These insights collectively contribute to the evolution of sophisticated drug delivery systems.

논문정보

형식Review Paper
게재일2023년 11월 (BRIC 등록일 2023-11-27)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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