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Chem. Soc. Rev., Nov 24 2023, | https://doi.org/10.1039/d3cs00709j Recent advances in point-of-care testing of COVID-19

Sungwoon Lee,^a Liyan Bi,^b Hao Chen,^c Dong Lin,^f Rongchao Me^i,d Yixuan Wu,^d Lingxin Chen,^*d,f Sang-Woo Joo^*e and Jaebum Choo^*a

^aDepartment of Chemistry, Chung-Ang University, Seoul 06974, South Korea

^bSchool of Special Education and Rehabilitation, Binzhou Medical University, Yantai, China

^cSchool of Environmental and Material Engineering, Yantai University, Yantai 264005, China

^dCAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Yantai 264003, China

^eDepartment of Information Communication, Materials, and Chemistry Convergence Technology, Soongsil University, Seoul 06978, South Korea

^fSchool of Pharmacy, Bianzhou Medical University, Yantai, China

^*Corresponding authors : Lingxin Chen, Sang-Woo Joo, Jaebum Choo

Abstract

Advances in microfluidic device miniaturization and system integration contribute to the development of portable, handheld, and smartphone-compatible devices. These advancements in diagnostics have the potential to revolutionize the approach to detect and respond to future pandemics. Accordingly, herein, recent advances in point-of-care testing (POCT) of coronavirus disease 2019 (COVID-19) using various microdevices, including lateral flow assay strips, vertical flow assay strips, microfluidic channels, and paper-based microfluidic devices, are reviewed. However, visual determination of the diagnostic results using only microdevices leads to many false-negative results due to the limited detection sensitivities of these devices. Several POCT systems comprising microdevices integrated with portable optical readers have been developed to address this issue. Since the outbreak of COVID-19, effective POCT strategies for COVID-19 based on optical detection methods have been established. They can be categorized into fluorescence, surface-enhanced Raman scattering, surface plasmon resonance spectroscopy, and wearable sensing. We introduced next-generation pandemic sensing methods incorporating artificial intelligence that can be used to meet global health needs in the future. Additionally, we have discussed appropriate responses of various testing devices to emerging infectious diseases and prospective preventive measures for the post-pandemic era. We believe that this review will be helpful for preparing for future infectious disease outbreaks.

논문정보

형식Review Paper
게재일2023년 11월 (BRIC 등록일 2023-11-27)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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