손영민 (성균관대학교 의과대학, 삼성서울병원) | 한빛사논문 > 한빛사

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성균관대학교 의과대학, 삼성서울병원

Adv. Sci., Nov 23 2023, | https://doi.org/10.1002/advs.202302404 Bidirectional Neuronal Control of Epileptiform Activity by Repetitive Transcranial Focused Ultrasound Stimulations

Taewon Choi ^1,†, Minseok Koo ^1,†, Jaesoon Joo ^{2 3}, Taekyung Kim^{4 5}, Young-Min Shon ^{2 3 4 5 *}, Jinhyoung Park ^{1 6 *}

¹Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, 16419, South Korea.
²Department of Health Sciences and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, 06351, South Korea.
³Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea.
⁴Biomedical Engineering Research Center, Samsung Medical Center, Seoul, 06351, South Korea.
⁵Department of Medical Device Management and Research, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, 06351, South Korea.
⁶Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 16419, South Korea.

^†These authors contributed equally to this work
^*Corresponding authors: correspondence to Young-Min Shon or Jinhyoung Park

Abstract

Repetitive stimulation procedures are used in neuromodulation techniques to induce persistent excitatory or inhibitory brain activity. The directivity of modulation is empirically regulated by modifying the stimulation length, interval, and strength. However, bidirectional neuronal modulations using ultrasound stimulations are rarely reported. This study presents bidirectional control of epileptiform activities with repetitive transcranial-focused ultrasound stimulations in a rat model of drug-induced acute epilepsy. It is found that repeated transmission of elongated (40 s), ultra-low pressure (0.25 MPa) ultrasound can fully suppress epileptic activities in electro-encephalography and cerebral blood volume measurements, while the change in bursting intervals from 40 to 20 s worsens epileptic activities even with the same burst length. Furthermore, the suppression induced by 40 s long bursts is transformed to excitatory states by a subsequent transmission. Bidirectional modulation of epileptic seizures with repeated ultrasound stimulation is achieved by regulating the changes in glutamate and γ-Aminobutyric acid levels, as confirmed by measurements of expressed c-Fos and GAD65 and multitemporal analysis of neurotransmitters in the interstitial fluid obtained via microdialysis.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2023-11-29)
연구진국내 연구진
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