안종민 (경희대학교)

한빛사논문

조회414

경희대학교

J. Am. Chem. Soc., Nov 23 2023, | https://doi.org/10.1021/jacs.3c09339 In Situ Activatable Nitrobenzene-Cysteine-Copper(II) Nano-complexes for Programmed Photodynamic Cancer Therapy

Jisoo Kang ¹, Hwajun Jeong ², Minseok Jeong³, Jaehoon Kim ¹, Sungnam Park ³, Junyang Jung ^1,2, Jong Min An ¹, Dokyoung Kim ^{1,2,4,5,6,7,8,9}

¹Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

²Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.

³Department of Chemistry and Research Institute for Natural Science, Korea University, Seoul 02841, Republic of Korea.

⁴Department of Precision Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

⁵Center for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea.

⁶KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea.

⁷UC San Diego Materials Research Science and Engineering Center, 9500 Gilman Drive, La Jolla, California 92093, United States.

⁸Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Core Research Institute (CRI), Kyung Hee University, Seoul 02447, Republic of Korea.

⁹Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

Corresponding Authors: Junyang Jung, Jong Min An, Dokyoung Kim

Abstract

Photodynamic therapy (PDT) has been used to reduce cancerous and precancerous cells via reactive oxygen species (ROS) generation from photosensitizers. Numerous photosensitizers are available today to treat a variety of diseases, but their therapeutic efficacy is hindered within the tumor microenvironment, and there are safety concerns associated with their non-specific activation. In this work, we disclosed a nano-therapeutic based on in situ activatable nitrobenzene-cysteine-copper(II) nano-complexes (NCCNs) that work within cancer cells. Among the NCCNs, CyP shows outstanding potential as a promising candidate for programmed photodynamic cancer therapy with its unique properties such as (i) bright near-infrared imaging, (ii) chemodynamic therapeutic effect, (iii) photodynamic therapeutic effect (types I and II), and (iv) anti-cancer effect by anti-angiogenesis in early cancer stage under light. Overall, this work opens up exciting possibilities for the development of innovative and effective treatments for cancer, paving the way for future advancements in the clinical medicine field.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2023-11-27)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

댓글 작성 로그인

CV 열람하기

연락처 보기