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듀크대학교, 현 포항공과대학

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Mol. Cell, November 22, 2023 | https://doi.org/10.1016/j.molcel.2023.10.030 Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana

Junbin Chen,^1,15 Lei Li,^2,9,15 Jong Hum Kim,^3,7,10,15 Benjamin Neuhauser,^4,15 Mingyu Wang,¹ Michael Thelen,^2,11 Richard Hilleary,³ Yuan Chi,³ Luyang Wei,¹ Kavita Venkataramani,^2,12 Moises Exposito-Alonso,^2,13 Chang Liu,^5,6 Jakob Keck,² A. Cristina Barragan,^2,14 Rebecca Schwab,² Ulrich Lutz,² Zhen-Ming Pei,³ Sheng-Yang He,^3,7Uwe Ludewig,⁴ Detlef Weigel,^2,8,* and Wangsheng Zhu ^1,2,16,*

¹China Key Laboratory of Pest Monitoring and Green Management, MOA, State Key Laboratory of Maize Bio-breeding, and College of Plant Protection, China Agricultural University, Beijing 100193, China
²Department of Molecular Biology, Max Planck Institute for Biology Tubingen, 72076 Tubingen, Germany
³Department of Biology, Duke University, Durham, NC 27708, USA
⁴Nutritional Crop Physiology, University of Hohenheim, 70599 Stuttgart, Germany
⁵Center for Plant Molecular Biology (ZMBP), University of Tubingen, 72076 Tubingen, Germany
⁶Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany
⁷Howard Hughes Medical Institute, Duke University, Durham, NC 27708, USA
⁸Institute for Bioinformatics and Medical Informatics, University of Tubingen, Tubingen, Germany
⁹Present address: Institute for Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
¹⁰Present address: Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea
¹¹Present address: Institute for Physical and Theoretical Chemistry, University Tubingen, 72076 Tubingen, Germany
¹²Present address: Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA
¹³Present address: Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305, USA
¹⁴Present address: The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK
¹⁵These authors contributed equally
¹⁶Lead contact

^*Corresponding authors: correspondence to Detlef Weigel or Wangsheng Zhu

Abstract

The multi-pass transmembrane protein ACCELERATED CELL DEATH 6 (ACD6) is an immune regulator in Arabidopsis thaliana with an unclear biochemical mode of action. We have identified two loci, MODULATOR OF HYPERACTIVE ACD6 1 (MHA1) and its paralog MHA1-LIKE (MHA1L), that code for ∼7 kDa proteins, which differentially interact with specific ACD6 variants. MHA1L enhances the accumulation of an ACD6 complex, thereby increasing the activity of the ACD6 standard allele for regulating plant growth and defenses. The intracellular ankyrin repeats of ACD6 are structurally similar to those found in mammalian ion channels. Several lines of evidence link increased ACD6 activity to enhanced calcium influx, with MHA1L as a direct regulator of ACD6, indicating that peptide-regulated ion channels are not restricted to animals.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2023-11-29)
연구진국외 연구진
분야 생명과학 > 식물학

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