한호현 (POSTECH)

한빛사논문

조회253

한호현Hohyeon Han

POSTECH

Nano Converg., Nov 15 2023, 10 (1) 52 | https://doi.org/10.1186/s40580-023-00402-5 Nanomaterials-incorporated hydrogels for 3D bioprinting technology

Jungbin Yoon^1†, Hohyeon Han^2† and Jinah Jang^1,2,3,4*

¹Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea

²School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea

³Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea

⁴Institute of Convergence Science, Yonsei University, Seoul, South Korea

^†Jungbin Yoon and Hohyeon Han contributed as co-frst authors.

^*Correspondence: Jinah Jang

Abstract

In the field of tissue engineering and regenerative medicine, various hydrogels derived from the extracellular matrix have been utilized for creating engineered tissues and implantable scaffolds. While these hydrogels hold immense promise in the healthcare landscape, conventional bioinks based on ECM hydrogels face several challenges, particularly in terms of lacking the necessary mechanical properties required for 3D bioprinting process. To address these limitations, researchers are actively exploring novel nanomaterial-reinforced ECM hydrogels for both mechanical and functional aspects. In this review, we focused on discussing recent advancements in the fabrication of engineered tissues and monitoring systems using nanobioinks and nanomaterials via 3D bioprinting technology. We highlighted the synergistic benefits of combining numerous nanomaterials into ECM hydrogels and imposing geometrical effects by 3D bioprinting technology. Furthermore, we also elaborated on critical issues remaining at the moment, such as the inhomogeneous dispersion of nanomaterials and consequent technical and practical issues, in the fabrication of complex 3D structures with nanobioinks and nanomaterials. Finally, we elaborated on plausible outlooks for facilitating the use of nanomaterials in biofabrication and advancing the function of engineered tissues.

논문정보

형식Review Paper
게재일2023년 11월 (BRIC 등록일 2023-11-21)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

댓글 작성 로그인

CV 열람하기

연락처 보기