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Northwestern University

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Biosens. Bioelectron., Oct 01 2023, 237 S0956-5663(23)00487-6 | https://doi.org/10.1016/j.bios.2023.115545 Simple, miniaturized biosensors for wireless mapping of thermoregulatory responses

Seyong Oh ^a,b,1, Jae-Young Yoo ^b,1, Woo-Youl Maeng ^b,1, Seonggwang Yoo ^b, Tianyu Yang ^b, Susan M. Slattery ^c,d, Sara Pessano ^c, Emily Chang ^b, Hyoyoung Jeong ^e, Jihye Kim^b, Hak-Young Ahn ^b, Yeongdo Kim ^b, Joohee Kim ^f, Shuai Xu ^b,g, Debra E. Weese-Mayer ^c,d, John A. Rogers ^b

^aDivision of Electrical Engineering, Hanyang University ERICA, Ansan, 15588, Republic of Korea

^bQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA

^cStanley Manne Children's Research Institute, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA

^dDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA

^eDepartment of Electrical and Computer Engineering, University of California Davis, Davis, CA, 95616, USA

^fCenter for Bionics, Biomedical Research Division, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea

^gSibel Health, Niles, IL, 60714, USA

¹These authors contributed equally to this work.

Corresponding authors : Seyong Oh, John A. Rogers

Abstract

Temperature is the most commonly collected vital sign in all of clinical medicine; it plays a critical role in care decisions related to topics ranging from infection to inflammation, sleep, and fertility. Most assessments of body temperature occur at isolated anatomical locations (e.g. axilla, rectum, temporal artery, or oral cavity). Even this relatively primitive mode for monitoring can be challenging with vulnerable patient populations due to physical encumbrances and artifacts associated with the sizes, weights, shapes and mechanical properties of the sensors and, for continuous monitoring, their hard-wired interfaces to data collection units. Here, we introduce a simple, miniaturized, lightweight sensor as a wireless alternative, designed to address demanding applications such as those related to the care of neonates in high ambient humidity environments with radiant heating found in incubators in intensive care units. Such devices can be deployed onto specific anatomical locations of premature infants for homeostatic assessments. The estimated core body temperature aligns, to within 0.05 °C, with clinical grade, wired sensors, consistent with regulatory medical device requirements. Time-synchronized, multi-device operation across multiple body locations supports continuous, full-body measurements of spatio-temporal variations in temperature and additional modes of determining tissue health status in the context of sepsis detection and various environmental exposures. In addition to thermal sensing, these same devices support measurements of a range of other essential vital signs derived from thermo-mechanical coupling to the skin, for applications ranging from neonatal and infant care to sleep medicine and even pulmonary medicine.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-11-20)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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