한빛사논문
Jae-Young Yoo 1,15, Seyong Oh 2,15, Wissam Shalish 3,15, Woo-Youl Maeng 1,15, Emily Cerier 4, Emily Jeanne 3, Myung-Kun Chung 5, Shasha Lv 3, Yunyun Wu 1, Seonggwang Yoo 1, Andreas Tzavelis 1, Jacob Trueb 1, Minsu Park 6, Hyoyoung Jeong 7, Efe Okunzuwa 4, Slobodanka Smilkova 8, Gyeongwu Kim 9, Junha Kim 10, Gooyoon Chung 10, Yoonseok Park 10, Anthony Banks 1, Shuai Xu 1,11, Guilherme M. Sant’Anna 3, Debra E. Weese-Mayer 12,13,14, Ankit Bharat 4,* & John A. Rogers 1,*
1Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
2Division of Electrical Engineering, Hanyang University ERICA, Ansan, Republic of Korea.
3Neonatal Division, Department of Pediatrics, McGill University Health Center, Montreal, Quebec, Canada.
4Division of Thoracic Surgery, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
5School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
6Department of Polymer Science and Engineering, Dankook University, Yongin, Republic of Korea.
7Department of Electrical and Computer Engineering, University of California, Davis, CA, USA.
8Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, USA.
9Adlai E. Stevenson High School, Lincolnshire, IL, USA.
10Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Gyeonggi-do, Republic of Korea.
11Sibel Health, Niles, IL, USA.
12Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
13Division of Autonomic Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA.
14Stanley Manne Children’s Research Institute, Chicago, IL, USA.
15These authors contributed equally: Jae-Young Yoo, Seyong Oh, Wissam Shalish, Woo-Youl Maeng.
*Corresponding authors: correspondence to Ankit Bharat or John A. Rogers
Abstract
The human body generates various forms of subtle, broadband acousto-mechanical signals that contain information on cardiorespiratory and gastrointestinal health with potential application for continuous physiological monitoring. Existing device options, ranging from digital stethoscopes to inertial measurement units, offer useful capabilities but have disadvantages such as restricted measurement locations that prevent continuous, longitudinal tracking and that constrain their use to controlled environments. Here we present a wireless, broadband acousto-mechanical sensing network that circumvents these limitations and provides information on processes including slow movements within the body, digestive activity, respiratory sounds and cardiac cycles, all with clinical grade accuracy and independent of artifacts from ambient sounds. This system can also perform spatiotemporal mapping of the dynamics of gastrointestinal processes and airflow into and out of the lungs. To demonstrate the capabilities of this system we used it to monitor constrained respiratory airflow and intestinal motility in neonates in the neonatal intensive care unit (n = 15), and to assess regional lung function in patients undergoing thoracic surgery (n = 55). This broadband acousto-mechanical sensing system holds the potential to help mitigate cardiorespiratory instability and manage disease progression in patients through continuous monitoring of physiological signals, in both the clinical and nonclinical setting.
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