한빛사논문
- 조회402
Min Young Chun, MD, PhD,1,2,3,a Seok Jong Chung, MD, PhD,1,2,3,a Su Hong Kim, MD, PhD,4,5,6 Chan Wook Park, MD,1,7 Seong Ho Jeong, MD,1,8 Hye Sun Lee, PhD,9 Phil Hyu Lee, MD, PhD,1 Young H. Sohn, MD, PhD,1 Yong Jeong, MD, PhD,4,5, 10,11 Yun Joong Kim, MD, PhD,1,2,3
1 Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea
2 Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, South Korea
3 YONSEI BEYOND LAB, Yongin, South Korea
4 Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
5 KAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
6 Department of Radiology, Yeungnam University College of Medicine, Daegu, South Korea
7 Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea
8 Department of Neurology, Inje University Sanggye Paik Hospital, Seoul, South Korea
9 Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea
10 Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
11 Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
a These authors contributed equally to this work.
Address for correspondence: Yun Joong Kim, MD, PhD
Abstract
Objectives: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson's disease (PD).
Methods: We recruited patients with newly diagnosed and non-medicated PD and healthy participants who underwent dual-phase 18 F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18 F-FP-CIT) positron emission tomography (PET) scans. Patients were classified into three groups according to hippocampal perfusion measured by standard uptake value ratios (SUVRs): 1) PD hippocampal hypoperfusion group (1 standard deviation [SD] below the mean hippocampal SUVR of healthy controls; PD-hippo-hypo), 2) PD hippocampal hyperperfusion group (1 SD above the mean; PD-hippo-hyper), and 3) the remaining patients (PD-hippo-normal). We compared the baseline cognitive performance, severity of motor deficits, hippocampal volume, striatal dopamine transporter (DAT) availability, and the risk of dementia conversion among the groups.
Results: We included 235 patients (PD-hippo-hypo: n = 21; PD-hippo-normal: n = 157; and PD-hippo-hyper: n = 57) and 48 healthy participants. Patients in PD-hippo-hypo group were older and had smaller hippocampal volumes than those in the other PD groups. PD-hippo-hypo group showed less severely decreased DAT availability in the putamen than the other groups despite similar severities of motor deficit. PD-hippo-hypo group had a higher risk of dementia conversion compared to PD-hippo-normal (hazard ratio, 2.59; p = 0.013) and PD-hippo-hyper (hazard ratio, 3.73; p = 0.006) groups, despite similar cognitive performance at initial assessment between groups.
Interpretation: Hippocampal hypoperfusion may indicate a reduced capacity to cope with neurodegenerative processes in terms of the development of motor deficits and cognitive decline in patients with PD.
논문정보
- Research article
- 2023년 11월 (BRIC 등록일 2023-11-27)
- 국내 연구진
- 바이오·의료융합 > 뇌인지과학
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