한빛사논문
- 조회157
Jimin Hong b,c,n, Jiaying Lu a,b,d,n, Fengtao Liu d,e,n, Min Wang f,g, Xinyi Li d,e, Christoph Clement b,c, Leonor Lopes b,c, Matthias Brendel h,k,l, Axel Rominger b, Tzu-Chen Yen i, Yihui Guan a,d, Mei Tian a,j,m, Jian Wang d,e, Chuantao Zuo a,d,j, Kuangyu Shi b,g
the Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)
Jian Wang, Fengtao Liu, Chuantao Zuo, Jianjun Wu, Yimin Sun, Ping Wu, Yilin Tang, Jue Zhao, Bin Wu, Bo Shen, Jiaying Lu, Xinyue Zhou, Xinyi Li, Huiwei Zhang, Jingjie Ge, Minjia Chen, Zizhao Ju
aDepartment of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China
bDepartment of Nuclear Medicine, Inselspital, University of Bern, Bern, Switzerland
cGraduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland
dNational Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China
eDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China
fInstitute of Biomedical Engineering, School of Life Science, Shanghai University, Shanghai, China
gDepartment of Informatics, Technical University of Munich, Munich, Germany
hDepartment of Nuclear Medicine, University of Munich, Munich, Germany
iAPRINOIA Therapeutics Co., Ltd, Suzhou, China
jHuman Phenome Institute, Fudan University, Shanghai, China
kGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany
lMunich Cluster for Systems Neurology (SyNergy), Munich, Germany
mInternational Human Phenome Institutes (Shanghai), Shanghai, China
nEqually contributed.
Corresponding authors: Jian Wang, Chuantao Zuo
Abstract
Background: Progressive supranuclear palsy (PSP) is a primary 4-repeat tauopathy with diverse clinical phenotypes. Previous post-mortem studies examined tau deposition sequences in PSP, but in vivo scrutiny is lacking.
Methods: We conducted [18F]Florzolotau tau positron emission tomography (PET) scans on 148 patients who were clinically diagnosed with PSP and 20 healthy controls. We employed the Subtype and Stage Inference (SuStaIn) algorithm to identify PSP subtype/stage and related tau patterns, comparing clinical features across subtypes and assessing PSP stage-clinical severity association. We also evaluated functional connectivity differences among subtypes through resting-state functional magnetic resonance imaging.
Findings: We identified two distinct subtypes of PSP: Subtype1 and Subtype2. Subtype1 typically exhibits a sequential progression of the disease, starting from subcortical and gradually moving to cortical regions. Conversely, Subtype2 is characterized by an early, simultaneous onset in both regions. Interestingly, once the disease is initiated, Subtype1 tends to spread more rapidly within each region compared to Subtype2. Individuals categorized as Subtype2 are generally older and exhibit less severe dysfunctions in areas such as cognition, bulbar, limb motor, and general motor functions compared to those with Subtype1. Moreover, they have a more favorable prognosis in terms of limb motor function. We found significant correlations between several clinical variables and the identified PSP SuStaIn stages. Furthermore, Subtype2 displayed a remarkable reduction in functional connectivity compared to Subtype1.
Interpretation: We present the evidence of distinct in vivo spatiotemporal tau trajectories in PSP. Our findings can contribute to precision medicine advancements for PSP.
논문정보
- Research article
- 2023년 11월 (BRIC 등록일 2024-03-12)
- 국외 연구진
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