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신상혁Sanghyuk S. Shin
University of California, Irvine
Emerg. Infect. Dis, Nov 2023, 29 (11) | https://doi.org/10.3201/eid2911.230987
Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
Chawangwa Modongo, Ivan Barilar, Qiao Wang, Tuduetso Molefi, Topo Makhondo, Stefan Niemann, and Sanghyuk S. Shin
Victus Global Botswana Organisation, Gaborone, Botswana (C. Modongo); Forschungszentrum, Borstel, Germany (I. Barilar, S. Niemann); University of California, Irvine, California, USA (Q. Wang, S.S. Shin); University of California, Los Angeles, California, USA (Q. Wang); Botswana Ministry of Health and Wellness, Gaborone (T. Molefi, T. Makhondo); German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany (S. Niemann)
Corresponding author : Sanghyuk S. Shin
Abstract
GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre-extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment.
논문정보
- Research Letter
- 2023년 11월 (BRIC 등록일 2024-03-12)
- 국외 연구진
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