한빛사논문
- 조회384
연세대학교
Dong-Min Lee 1,2,10, Minki Kang 3,10, Inah Hyun 1,2,10, Byung-Joon Park 1,2, Hye Jin Kim 4, Soo Hyun Nam 5, Hong-Joon Yoon 6, Hanjun Ryu 7, Hyun-moon Park 8, Byung-Ok Choi 4,5,9,* & Sang-Woo Kim 1,2,*
1Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.
2Center for Human-oriented Triboelectric Energy Harvesting, Yonsei University, Seoul 03722, Republic of Korea.
3School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea. 4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
5Cell and Gene Therapy Institute (CGTI), Samsung Medical Center, Seoul 06351, Republic of Korea.
6Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea.
7Department of Advanced Materials Engineering, Chung-Ang University, Anseong 17546, Republic of Korea.
8Research and Development Center, Energy-Mining Co., LTD., Suwon 16226, Republic of Korea.
9Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Seoul 06351, Republic of Korea.
10These authors contributed equally: Dong-Min Lee, Minki Kang, Inah Hyun.
*Corresponding authors: correspondence to Byung-Ok Choi or Sang-Woo Kim
Abstract
Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their practical application in medical settings. First, they necessitate sustainable energy solutions with biodegradable components via biosafe powering mechanisms. More importantly, reliability in their function is undermined by unpredictable device lifetimes due to the complex polymer degradation kinetics. Here, we propose an on-demand bioresorbable neurostimulator to address these issues, thus allowing for clinical operations to be manipulated using biosafe ultrasound sources. Our ultrasound-mediated transient mechanism enables (1) electrical stimulation through transcutaneous ultrasound-driven triboelectricity and (2) rapid device elimination using high-intensity ultrasound without adverse health effects. Furthermore, we perform neurophysiological analyses to show that our neurostimulator provides therapeutic benefits for both compression peripheral nerve injury and hereditary peripheral neuropathy. We anticipate that the on-demand bioresorbable neurostimulator will prove useful in the development of medical implants to treat peripheral neuropathy.
논문정보
- Research article
- 2023년 11월 (BRIC 등록일 2023-11-24)
- 국내 연구진
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