윤인아 (연세대학교 약학대학) | 한빛사논문 > 한빛사

한빛사논문

조회582

윤인아Ina Yoon

연세대학교 약학대학

Trends Mol. Med , Nov 08 2023, S1471-4914(23)00241-1 | https://doi.org/10.1016/j.molmed.2023.10.006 Disease association and therapeutic routes of aminoacyl-tRNA synthetases

Ina Yoon ^1,4, Uijoo Kim ^1,4, Jaeyoung Choi ¹, Sunghoon Kim ^1,2,3

¹Institute for Artificial Intelligence and Biomedical Research, Medicinal Bioconvergence Research Center, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea

²College of Medicine, Gangnam Severance Hospital, Yonsei University, Seoul 06273, Republic of Korea

³Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Incheon 21983, Republic of Korea

⁴These authors contributed equally to this work.

Correspondence: Sunghoon Kim

Abstract

Aminoacyl-tRNA synthetases (ARSs) are enzymes that catalyze the ligation of amino acids to tRNAs for translation. Beyond their traditional role in translation, ARSs have acquired regulatory functions in various biological processes (epi-translational functions). With their dual-edged activities, aberrant expression, secretion, and mutations of ARSs are associated with human diseases, including cancer, autoimmune diseases, and neurological diseases. The increasing numbers of newly unveiled activities and disease associations of ARSs have spurred interest in novel drug development, targeting disease-related catalytic and noncatalytic activities of ARSs as well as harnessing ARSs as sources for biological therapeutics. This review speculates how the translational and epi-translational activities of ARSs can be related and describes how their activities can be linked to diseases and drug discovery.

논문정보

형식Review Paper
게재일2023년 11월 (BRIC 등록일 2023-11-14)
연구진국내 연구진
분야 의약학 > 약학

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