배태옥 (Indiana University School of Medicine-Northwest)

한빛사논문

조회115

Indiana University School of Medicine-Northwest

Emerg. Microbes Infect., Dec 2023, 12 (2) | https://doi.org/10.1080/22221751.2023.2276335 Diabetes mellitus promotes the nasal colonization of high virulent Staphylococcus aureus through the regulation of SaeRS two-component system

Qichen Wang ¹, Nadira Nurxat ¹, Lei Zhang ², Yao Liu ¹, Yanan Wang ¹, Lei Zhang³, Na Zhao ¹, Yingxin Dai ¹, Ying Jian¹, Lei He¹, Hua Wang ¹, Taeok Bae⁴, Min Li ^1,5, Qian Liu ¹

¹Department of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

²Department of Vascular Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

³Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Anhui Medical University, Hefei, People's Republic of China.

⁴Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, IN, USA.

⁵Faculty of Medical Laboratory Science, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Correspondence : Hua Wang, Taeok Bae, Min Li, Qian Liu

Abstract

Diabetic foot infections are a common complication of diabetes. Staphylococcus aureus is frequently isolated from diabetic foot infections and commonly colonizes human nares. According to the study, the nasal microbiome analysis revealed that diabetic patients had a significantly altered nasal microbial composition and diversity. Typically, the fasting blood glucose (FBG) level had an impact on the abundance and sequence type (ST) of S. aureus in diabetic patients. We observed that highly virulent S. aureus ST7 strains were more frequently colonized in diabetic patients, especially those with poorly controlled FBG, while ST59 was dominant in healthy individuals. S. aureus ST7 strains were more resistant to human antimicrobial peptides and formed stronger biofilms than ST59 strains. Critically, S. aureus ST7 strains displayed higher virulence compared to ST59 strains in vivo. The dominance of S. aureus ST7 strains in hyperglycemic environment is due to the higher activity of the SaeRS two-component system (TCS). S. aureus ST7 strains outcompeted ST59 both in vitro, and in nasal colonization model in diabetic mice, which was abolished by the deletion of the SaeRS TCS. Our data indicated that highly virulent S. aureus strains preferentially colonize diabetic patients with poorly controlled FBG through SaeRS TCS. Detection of S. aureus colonization and elimination of colonizing S. aureus are critical in the care of diabetic patients with high FBG.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2024-03-12)
연구진국외 연구진
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