한빛사논문
- 조회527
TaeHyun Kim,1,4, Dong Il Choi,1,4, Ja Eun Choi,1,4, Hoonwon Lee,1,2, Hyunsu Jung,1,2, Jooyoung Kim,1,2, Yongmin Sung,1,2, HyoJin Park,1,2, Min Jung Kim,1, Dae Hee Han,1,2, Seung-Hee Lee,3 and Bong-Kiun Kaang1,2,5,*
1Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, South Korea
2Center for Cognition and Sociality, Life Science Institute, Institute for Basic Science (IBS), Daejeon 34141, South Korea
3Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 34141, South Korea
4These authors contributed equally
5Lead contact
*Correspondence: Bong-Kiun Kaang
Abstract
Despite recent advancements in identifying engram cells, our understanding of their regulatory and functional mechanisms remains in its infancy. To provide mechanistic insight into engram cell functioning, we introduced a novel local microcircuit labeling technique that enables the labeling of intraregional synaptic connections. Utilizing this approach, we discovered a unique population of somatostatin (SOM) interneurons in the mouse basolateral amygdala (BLA). These neurons are activated during fear memory formation and exhibit a preference for forming synapses with excitatory engram neurons. Post-activation, these SOM neurons displayed varying excitability based on fear memory retrieval. Furthermore, when we modulated these SOM neurons chemogenetically, we observed changes in the expression of fear-related behaviors, both in a fear-associated context and in a novel setting. Our findings suggest that these activated SOM interneurons play a pivotal role in modulating engram cell activity. They influence the expression of fear-related behaviors through a mechanism that is dependent on memory cues.
논문정보
- Research article
- 2023년 11월 (BRIC 등록일 2023-11-10)
- 국내 연구진
- 생명과학 > 신경생물학
관련 보도자료
- Bio통신원
- 2023. 11. 09
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