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Trends Cancer, Oct 18 2023, S2405-8033(23)00212-1 | https://doi.org/10.1016/j.trecan.2023.10.001
Making normal hematopoiesis invisible to CAR T cells
Miriam Y. Kim 1
1Washington University School of Medicine, Saint Louis, MO, USA
Correspondence: Miriam Y. Kim
Abstract
Two recent studies, by Casirati et al. and Wellhausen et al., report genetically engineering normal hematopoietic stem and progenitor cells (HSPCs) to be resistant to chimeric antigen receptor (CAR)-T cells, by changing a single amino acid in the target protein that abrogates CAR binding, without compromising protein function. This allows for selective targeting of cancer cells without harming normal hematopoietic cells.
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- 2023년 10월 (BRIC 등록일 2023-11-09)
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