표영우 (서울대학교, 고려대학교)

한빛사논문

조회312

표영우Young-Woo Pyo

서울대학교, 고려대학교

Nat. Commun., Nov 04 2023, 14 (1) 7088 | https://doi.org/10.1038/s41467-023-42860-9 The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity

Jung Min Lee^1,5, Young-Woo Pyo^1,2,5, Yeon Jun Kim², Jin Hee Hong^2,3, Yonghyeon Jo^2,3, Wonshik Choi^2,3, Dingchang Lin⁴ & Hong-Gyu Park¹

¹Department of Physics and Astronomy, and Institute of Applied Physics, Seoul National University, Seoul 08826, Republic of Korea.

²Department of Physics, Korea University, Seoul 02841, Republic of Korea.

³Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science, Seoul 02841, Republic of Korea.

⁴Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

⁵These authors contributed equally: Jung Min Lee, Young-Woo Pyo.

Corresponding author : Correspondence to Hong-Gyu Park.

Abstract

Electrophysiological recording technologies can provide valuable insights into the functioning of the central and peripheral nervous systems. Surface electrode arrays made of soft materials or implantable multi-electrode arrays with high electrode density have been widely utilized as neural probes. However, neither of these probe types can simultaneously achieve minimal invasiveness and robust neural signal detection. Here, we present an ultra-thin, minimally invasive neural probe (the "NeuroWeb") consisting of hexagonal boron nitride and graphene, which leverages the strengths of both surface electrode array and implantable multi-electrode array. The NeuroWeb open lattice structure with a total thickness of 100 nm demonstrates high flexibility and strong adhesion, establishing a conformal and tight interface with the uneven mouse brain surface. In vivo electrophysiological recordings show that NeuroWeb detects stable single-unit activity of neurons with high signal-to-noise ratios. Furthermore, we investigate neural interactions between the somatosensory cortex and the cerebellum using transparent dual NeuroWebs and optical stimulation, and measure the times of neural signal transmission between the brain regions depending on the pathway. Therefore, NeuroWeb can be expected to pave the way for understanding complex brain networks with optical and electrophysiological mapping of the brain.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2023-11-09)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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