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Adv. Healthc. Mater., Nov 07 2023 | https://doi.org/10.1002/adhm.202303244
CSMP, A Self-Assembled Plant Polysaccharide-based Hydrofilm for Enhanced Wound Healing
Zhen Qiao,1,4, KeLun Zhang,2,3,4, Huifang Liu,1, Yeonjeong Roh,1, Myoung Gyu Kim,1, Hyo Joo Lee,1, Bonhan Koo,1, Eun Yeong Lee,1, Minju Lee,1, Chang Ook Park,2,3,* and Yong Shin1,5,*
1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea
2Department of Dermatology, Severance, Hospital, Cutaneous Biology, Research Institute, Yonsei University College of Medicine, Seoul, Korea
3Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
4These authors (Z.Q. and K.Z) contributed equally to this work
5Lead contact
*Correspondence: Y.S., C.O.P.
Abstract
Wound management remains a critical healthcare issue due to the rising incidence of chronic diseases leading to persistent wounds. Traditional dressings have their limitations, such as potential for further damage during changing and suboptimal healing conditions. Recently, hydrogel-based dressings have gained attention due to their biocompatibility, biodegradability, and ability to fill wounds. Particularly, polysaccharide-based hydrogels have shown potential in various medical applications. This study focuses on the development of a novel hydrofilm wound dressing produced from a blend of Chia Seed Mucilage (CSM) and Polyvinyl Alcohol (PVA), termed CSMP. While the individual properties of CSM and PVA are well-documented, their combined potential in wound management is largely unexplored. CSMP, coupled with sorbitol and glycerin, and cross-linked using ultraviolet light, resulted in a flexible, adhesive, and biocompatible hydrofilm demonstrating superior water absorption, moisturizing, and antibacterial properties. This hydrofilm promoted epithelial cell migration, enhanced collagen production, and outperformed existing commercial dressings in animal tests. The innovative CSMP hydrofilm offers a promising, cost-effective approach for improved wound care, bridging existing gaps in dressing performance and preparation simplicity. Future research can unlock further applications of such polysaccharide-based hydrofilm dressings. This article is protected by copyright. All rights reserved.
논문정보
- Research article
- 2023년 11월 (BRIC 등록일 2023-11-10)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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