박소정 (City University of Hong Kong)

한빛사논문

조회362

박소정PAK SOJEONG

City University of Hong Kong

Prog. Neurobiol., Nov 02 2023, S0301-0082(23)00144-2 | https://doi.org/10.1016/j.pneurobio.2023.102543 Cortical surface plasticity promotes map remodeling and alleviates tinnitus in adult mice

Sojeong Pak ^a,1, Minseok Lee ^a,b,1, Sangwon Lee ^b,d, Huilin Zhao ^a, Eunha Baeg^b, Sunggu Yang ^b,c,d, Sungchil Yang ^a

^aDepartment of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong

^bDepartment of Nano-bioengineering, Incheon National University, Incheon, 22012, Republic of Korea

^cCenter for Brain-Machine Interface, Incheon National University, Incheon, 22012, Republic of Korea

^dgBrain Inc., Incheon 21984, Republic of Korea

¹These authors contributed equally to this work.

Corresponding authors: Sunggu Yang, Sungchil Yang

Abstract

Tinnitus induced by hearing loss is caused primarily by irreversible damage to the peripheral auditory system, which results in abnormal neural responses and frequency map disruption in the central auditory system. It remains unclear whether and how electrical rehabilitation of the auditory cortex can alleviate tinnitus. We hypothesize that stimulation of the cortical surface can alleviate tinnitus by enhancing neural responses and promoting frequency map reorganization. To test this hypothesis, we assessed and activated cortical maps using our newly designed graphene-based electrode array with a noise-induced tinnitus animal model. We found that cortical surface stimulation increased cortical activity, reshaped sensory maps, and alleviated hearing loss-induced tinnitus behavior in adult mice. These effects were likely due to retained long-term synaptic potentiation capabilities, as shown in cortical slices from the mice model. These findings suggest that cortical surface activation can be used to facilitate practical functional recovery from phantom percepts induced by sensory deprivation. They also provide a working principle for various treatment methods that involve electrical rehabilitation of the cortex.

논문정보

형식Research article
게재일2023년 11월 (BRIC 등록일 2023-11-07)
연구진국내(교신)+국외 연구진
분야 생명과학 > 신경생물학

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