Yunjie Xu (고려대학교)

한빛사논문

조회311

고려대학교

Coord. Chem. Rev., Available online 27 October 2023 | https://doi.org/10.1016/j.ccr.2023.215481 Covalent organic framework nanoparticles: Overcoming the challenges of hypoxia in cancer therapy

Nem Singh ^a,b,1, Miae Won ^a,c,1, Yunjie Xu ^a,1, Changyu Yoon ^a, Jiyoung Yoo ^a, Mingle Li ^d, Heemin Kang ^b, Jong Seung Kim ^a,c

^aDepartment of Chemistry, Korea University, Seoul 02841, Korea

^bDepartment of Materials Science and Engineering, Korea University, Seoul 02841, Korea

^cTheranoChem Incorporation, Seongbuk-gu, Seoul 02856, Korea

^dState Key Laboratory of Fine Chemicals, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China

¹These authors contributed equally to this work.

Corresponding authors : Mingle Li, Heemin Kang, Jong Seung Kim

Abstract

Hypoxia, or low oxygen levels, is a common feature of the tumor microenvironment. It is caused by the aggressive proliferation of cancer cells, which consume more oxygen than healthy cells. Hypoxia not only activates several signaling pathways that promote tumor growth, and metastasis but also increases resistance to conventional cancer treatments. The introduction of covalent organic frameworks (COFs), with their porous structure, high stability, tunable properties, large surface area, and unrivaled biocompatibility, has offered promising prospects for resolving hypoxia-specific challenges. This write-up critically explores the COFs in enhancing oxygen delivery, reactive oxygen species (ROS) generation, optimized drug delivery, and enabling hypoxia-specific imaging. Furthermore, it outlines how COFs facilitate various hypoxia-targeting therapeutic modalities such as chemotherapy, type-I and type-II photodynamic therapy, photothermal therapy, sonodynamic therapy, and immunotherapy. By evaluating the latest research findings and their implications, this review offers insights into the potent role of COFs in curtailing hypoxia and bolstering cancer treatment efficiency. The overarching goal of this assessment is to enrich our understanding of hypoxia-specific cancer therapy strategies, crediting the pivotal role of COFs. It is hoped that this greater comprehension of the abilities and constraints of COFs will pave the way to conceive more potent and targeted therapeutic interventions, thereby enhancing patient outcomes in the complex terrain of cancer therapeutics.

논문정보

형식Review Paper
게재일2023년 10월 (BRIC 등록일 2023-11-03)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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