한빛사논문
- 조회674
Kiho Kim1,13, In Sik Min1,13, Tae Hee Kim2,3,13, Do Hyeon Kim4, Seungwon Hwang5, Kyowon Kang1, Kyubeen Kim1, Sangun Park2,6, Jongmin Lee7, Young Uk Cho1, Jung Woo Lee8, Woon-Hong Yeo9,10,11, Young Min Song4, Youngmee Jung2,12 and Ki Jun Yu1,12
1Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
3Department of Fusion Research and Collaboration, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
4School of Electrical Engineering and Computer Science (EECS), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
5PA1, Foundry Business, Samsung Electronics, 1 Samsungjeonja-ro, Hwaseong-si, Gyeonggi-do, Republic of Korea.
6R&D Center DNA Lab, Pharmaresearch, Seongnam 13486, Republic of Korea.
7KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-705, Republic of Korea.
8School of Materials Science and Engineering, Energy Materials for Soft Electronics Laboratory, Pusan National University, Busan 46241, Republic of Korea.
9IEN Center for Human-Centric Interfaces and Engineering and George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
10Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
11Institute for Robotics and Intelligent Machines, Parker H. Petit Institute for Bioengineering and Biosciences, Institute for Materials, Neural Engineering Center, Georgia Institute of Technology, Atlanta, GA 30332, USA.
12School of Electrical and Electronic Engineering, YU-Korea Institute of Science and Technology (KIST) Institute, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
13These authors contributed equally: Kiho Kim, In Sik Min, Tae Hee Kim.
Corresponding authors : Correspondence to Young Min Song, Youngmee Jung or Ki Jun Yu.
Abstract
Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (μ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of μ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-11-01)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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