한빛사논문
- 조회463
Young Uk Cho1, Kyeongmin Kim2,3, Ankan Dutta4,5, Sang Hoon Park1, Ju Young Lee1, Hyun Woo Kim1, Jieon Park1, Jiwon Kim3,6, Won Kyung Min1,7, Chihyeong Won1, Jaejin Park1, Yujin Kim8, Jong Youl Kim6, Taeyoon Lee1, Hyun Jae Kim1,7, Donghyun Kim1, Jong Eun Lee3,6,9, Byung-Wook Min1, Il-Joo Cho6,8, Bae Hwan Lee3,10, Huanyu Cheng4,11,12, Myeounghoon Cha,2* and Ki Jun Yu1,13*
1Department of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722 Republic of Korea
2Department of Physiology, Yonsei University College of Medicine, Seoul, 03722 Republic of Korea
3Department of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722 Republic of Korea
4Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802 USA
5Center for Neural Engineering, The Pennsylvania State University, State College, University Park, PA, 16802 USA
6Department of Anatomy, Yonsei University College of Medicine, Seoul, 03722 Republic of Korea
7Electronic Device Laboratory, School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722 Republic of Korea
8Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, 02841 Republic of Korea
9Brain Research Institute, Yonsei University College of Medicine, Seoul, 03722 Republic of Korea
10Department of Physiology, Yonsei University College of Medicine, Seoul, 03722 Republic of Korea
11Department of Materials Science and Engineering, The Pennsylvania State University, State College, University Park, PA, 16802 USA
12Materials Research Institute, The Pennsylvania State University, State College, University Park, PA, 16802 USA
13Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul, 03722 Republic of Korea
Y.U.C. and K.K. contributed equally to this work.
*CORRESPONDING AUTHORS : Myeounghoon Cha, Ki Jun Yu
Abstract
Simultaneous monitoring of electrophysiology and magnetic resonance imaging (MRI) could guide the innovative diagnosis and treatment of various neurodegenerative diseases that are previously impossible. However, this technique is difficult because the existing metal-based implantable neural interface for electrophysiology is not free from signal distortions from its intrinsic magnetic susceptibility while performing an MRI of the implanted area of the neural interface. Moreover, brain tissue heating from neural implants generated by the radiofrequency field from MRI poses potential hazards for patients. Previous studies with soft polymer-based electrode arrays provide relatively suitable MRI compatibility but does not guarantee high-resolution electrophysiological signal acquisition and stimulation performance. Here, MRI compatible, optically transparent flexible implantable device capable of electrophysiological multichannel mapping and electrical stimulation is introduced. Using the device, neuropathic pain (NP) relief with a 30-channel electrophysiological mapping of the somatosensory area before and after motor cortex stimulation (MCS) in allodynia rats after noxious stimulation is confirmed. Additionally, artifact-free manganese-enhanced MRI of dramatic relief of pain-related region activity by MCS is demonstrated. Furthermore, artifact-free optogenetics with transgenic mice is also investigated by recording light-evoked potentials. These results suggest a promising neuro-prosthetic for analyzing and modulating spatiotemporal neurodynamic without MRI or optical modality resolution constraints.
논문정보
- Research article
- 2023년 10월 (BRIC 등록일 2023-11-01)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 의료기기
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