KAIST, 가톨릭대학교 의과대학
Karen-Christian Agno 1,5, Keungmo Yang 2,3,5, Sang-Hyuk Byun 1, Subin Oh 1, Simok Lee 1, Heesoo Kim 1, Kyurae Kim 2, Sungwoo Cho 1, Won-Il Jeong 2,* & Jae-Woong Jeong 1,4,*
1School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
3Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
4KAIST Institute for Health Science and Technology, Daejeon, Republic of Korea.
5These authors contributed equally: Karen-Christian Agno, Keungmo Yang.
*Corresponding authors: correspondence to Won-Il Jeong or Jae-Woong Jeong
The high stiffness of intravenous needles can cause tissue injury and increase the risk of transmission of blood-borne pathogens through accidental needlesticks. Here we describe the development and performance of an intravenous needle whose stiffness and shape depend on body temperature. The needle is sufficiently stiff for insertion into soft tissue yet becomes irreversibly flexible after insertion, adapting to the shape of the blood vessel and reducing the risk of needlestick injury on removal, as we show in vein phantoms and ex vivo porcine tissue. In mice, the needles had similar fluid-delivery performance and caused substantially less inflammation than commercial devices for intravenous access of similar size. We also show that an intravenous needle integrated with a thin-film temperature sensor can monitor core body temperature in mice and detect fluid leakage in porcine tissue ex vivo. Temperature-responsive intravenous needles may improve patient care.