한빛사논문
- 조회616
In-Jee You1,2,4, Yeeun Bae1,2,3,4, Alec R. Beck1,2 & Sora Shin1,2,3
1Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
2FBRI Center for Neurobiology Research, Roanoke, VA, USA.
3Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
4These authors contributed equally: In-Jee You, Yeeun Bae.
Corresponding author : Correspondence to Sora Shin.
Abstract
Psychological stressors, like the nearby presence of a predator, can be strong enough to induce physiological/hormonal alterations, leading to appetite changes. However, little is known about how threats can alter feeding-related hypothalamic circuit functions. Here, we found that proenkephalin (Penk)-expressing lateral hypothalamic (LHPenk) neurons of mice exposed to predator scent stimulus (PSS) show sensitized responses to high-fat diet (HFD) eating, whereas silencing of the same neurons normalizes PSS-induced HFD overconsumption associated with a negative emotional state. Downregulation of endogenous enkephalin peptides in the LH is crucial for inhibiting the neuronal and behavioral changes developed after PSS exposure. Furthermore, elevated corticosterone after PSS contributes to enhance the reactivity of glucocorticoid receptor (GR)-containing LHPenk neurons to HFD, whereas pharmacological inhibition of GR in the LH suppresses PSS-induced maladaptive behavioral responses. We have thus identified the LHPenk neurons as a critical component in the threat-induced neuronal adaptation that leads to emotional overconsumption.
논문정보
- Research article
- 2023년 10월 (BRIC 등록일 2023-10-31)
- 국외 연구진
- 의약학 > 신경의학
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