한빛사논문
- 조회618
Sagang Koo 1,2,17, Hee Su Sohn 2,17, Tae Hee Kim 3,4,17, Siyeon Yang 3,5, Se Youn Jang 3,6, Seongryeol Ye 3,7, Boomin Choi 1, Soo Hyeon Kim 8, Kyoung Sun Park 8, Hyun Mu Shin 8,9,10, Ok Kyu Park 1, Cheesue Kim 2, Mikyung Kang 11,12, Min Soh 1, Jin Yoo 3, Dokyoon Kim 13, Nohyun Lee 14, Byung-Soo Kim 2,15,*, Youngmee Jung 3,16,* & Taeghwan Hyeon 1,2,*
1Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.
2School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea.
3Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
4Department of Fusion Research and Collaboration, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
5Animal Research Laboratory, Institute Pasteur Korea, Seongnam, Republic of Korea.
6Department of Dentistry, Graduate School, Kyung Hee University, Seoul, Korea.
7Program in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.
8Wide River Institute of Immunology, Seoul National University, Hongcheon, Republic of Korea.
9Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
10BK21 FOUR Biomedical Science Project, Seoul National University College of Medicine, Seoul, Republic of Korea.
11Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
12Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
13Department of Bionano Engineering and Bionanotechnology, Hanyang University, Ansan, Republic of Korea.
14School of Advanced Materials Engineering, Kookmin University, Seoul, Republic of Korea.
15Interdisciplinary Program for Bioengineering, Institute of Engineering Research, Seoul National University, Seoul, Republic of Korea.
16School of Electrical and Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul, Republic of Korea.
17These authors contributed equally: Sagang Koo, Hee Su Sohn, Tae Hee Kim.
*Corresponding authors: correspondence to Byung-Soo Kim, Youngmee Jung or Taeghwan Hyeon
Abstract
Commencing with the breakdown of immune tolerance, multiple pathogenic factors, including synovial inflammation and harmful cytokines, are conjointly involved in the progression of rheumatoid arthritis. Intervening to mitigate some of these factors can bring a short-term therapeutic effect, but other unresolved factors will continue to aggravate the disease. Here we developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to address multiple factors in rheumatoid arthritis. Each component of this nanohybrid works individually and also synergistically, resulting in comprehensive treatment. Alleviation of inflammation and modulation of the tissue environment into an immunotolerant-favourable state are combined to recover the immune system by bridging innate and adaptive immunity. The therapy is shown to successfully treat and prevent rheumatoid arthritis by relieving the main symptoms and also by restoring the immune system through the induction of regulatory T cells in a mouse model of collagen-induced arthritis.
논문정보
- Research article
- 2023년 10월 (BRIC 등록일 2023-10-30)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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