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한빛사논문
- 조회468
Nano Converg., Oct 21 2023, 10 (1) | https://doi.org/10.1186/s40580-023-00398-y
Nano-biomaterials and advanced fabrication techniques for engineering skeletal muscle tissue constructs in regenerative medicine
Seokgyu Han1,2, Sebastián Herrera Cruz1, Sungsu Park2,3* and Su Ryon Shin1*
1Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
2School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea
3Department of Biophysics, Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon 16419, Korea
*Correspondence: Sungsu Park, Su Ryon Shin
Abstract
Engineered three-dimensional (3D) tissue constructs have emerged as a promising solution for regenerating damaged muscle tissue resulting from traumatic or surgical events. 3D architecture and function of the muscle tissue constructs can be customized by selecting types of biomaterials and cells that can be engineered with desired shapes and sizes through various nano- and micro-fabrication techniques. Despite significant progress in this field, further research is needed to improve, in terms of biomaterials properties and fabrication techniques, the resemblance of function and complex architecture of engineered constructs to native muscle tissues, potentially enhancing muscle tissue regeneration and restoring muscle function. In this review, we discuss the latest trends in using nano-biomaterials and advanced nano-/micro-fabrication techniques for creating 3D muscle tissue constructs and their regeneration ability. Current challenges and potential solutions are highlighted, and we discuss the implications and opportunities of a future perspective in the field, including the possibility for creating personalized and biomanufacturable platforms.
논문정보
- Review Paper
- 2023년 10월 (BRIC 등록일 2023-10-26)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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