한빛사논문
- 조회932
Hyunsun Jeong a, Xiaofeng Wu a,c, Jun-Seok Lee b, Juyoung Yoon a
aDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea
bDepartment of Pharmacology, Korea University College of Medicine, 73 Goryeodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea
cState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
Corresponding authors: Xiaofeng Wu. Jun-Seok Lee, Juyoung Yoon
Abstract
Enzymes and their regulations are employed as indicators for various diseases, including cancer. To directly analyze the activity of the enzymes within a biological system, enzyme-activated near-infrared (NIR) fluorescent probes are being continuously developed. These probes enable clear imaging of enzyme activity in real time with high spatiotemporal resolution, while preserving their unique advantages such as high sensitivity, reduced autofluorescence, and low light scattering. Enzyme expression levels can also be investigated by evaluating the emission intensity. Owing to these strengths, enzyme-activated NIR fluorescent probes have been applied in various clinical areas such as biomedical imaging, quantitative analysis, and surgery. Therefore, the development of NIR fluorescent probes that could be specifically activated by disease-related enzymes is a crucial task. In this review, we introduce several enzymes associated with disorders and summarize the relevant activated NIR fluorescent probes reported from 2020 to 2023.
논문정보
- Review Paper
- 2023년 11월 (BRIC 등록일 2023-10-19)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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