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Adv. Healthc. Mater., Oct 17 2023, | https://doi.org/10.1002/adhm.202302121
Platelet Membrane-Enclosed Bioorthogonal Catalysis for Combating Dental Caries
Mamata Karmacharya 1,2, Sumit Kumar 1,3*, Yoon Jeong Choi 4, Yoon-Kyoung Cho 1,3*
1Center for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan, 44919, South Korea.
2School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, South Korea.
3Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, South Korea.
4Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University, College of Dentistry, Seoul, South Korea.
*CORRESPONDING AUTHOR : Sumit Kumar, Yoon-Kyoung Cho
Abstract
Platelets have shown promise as a means to combat bacterial infections, fostering the development of innovative therapeutic approaches. However, several challenges persist, including cargo loading issues, limited efficacy against biofilms, and concerns regarding the impact of payloads on the platelet carriers. Here, we introduce human platelet membrane vesicles (h-PMVs) encapsulating supramolecular metal catalysts (SMCs) as "nanofactories" to convert prodrugs into antimicrobial compounds within close proximity to bacteria. Having established the feasibility and effectiveness of the SMCs within h-PMVs, referred to as the PLT-reactor, to activate pro-antibiotic drugs (pro-ciprofloxacin and pro-moxifloxacin) using model organisms (Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923), we subsequently extended our investigation to oral biofilms, with a particular emphasis on Streptococcus mutans 3065. This "bind and kill" strategy demonstrates the potent antimicrobial specificity of the PLT-reactor through localized antibiotic production. h-PMVs play a pivotal role by enabling precise targeting of pathogenic biofilms on natural teeth while minimizing potential hemolytic effects. Our finding indicates that platelet membrane-cloaked surfaces exhibit robust, multifaceted, and pathogen-specific binding affinity with excellent biocompatibility, making them a promising alternative to antibody-based therapies for infectious diseases. This article is protected by copyright. All rights reserved.
논문정보
- Research article
- 2023년 10월 (BRIC 등록일 2023-10-18)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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