강하라 (인천대학교)

한빛사논문

조회284

강하라Hara Kang

인천대학교

J. Biomed. Sci., Oct 16 2023, 30 (1) | https://doi.org/10.1186/s12929-023-00981-9 Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges

Hara Kang¹, Yun Ji Ga¹, Soo Hyun Kim¹, Young Hoon Cho¹, Jung Won Kim^1,3, Chaeyeon Kim¹ and Jung‑Yong Yeh^1,2,3,4*

¹Department of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Academy‑Ro 119, Yeonsu‑Gu, Incheon 22012, South Korea

²Research Institute for New Drug Development, Incheon National University, Academy‑Ro 119, Yeonsu‑Gu, Incheon 22012, South Korea

³Convergence Research Center for Insect Vectors, Incheon National University, Academy‑Ro 119, Yeonsu‑Gu, Incheon 22012, South Korea

⁴KU Center for Animal Blood Medical Science, College of Veterinary Medicine, Konkuk University, 120 Neungdong‑Ro, Gwangjin‑Gu, Seoul 05029, South Korea

^*Correspondence: Jung‑Yong Yeh

Abstract

RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic. Since their development in the 1990s, RNA interference (RNAi) therapeutics have demonstrated potential in reducing the expression of disease-associated genes. Nucleic acid-based therapeutics, including RNAi therapies, that degrade viral genomes and rapidly adapt to viral mutations, have emerged as alternative treatments. RNAi is a robust technique frequently employed to selectively suppress gene expression in a sequence-specific manner. The swift adaptability of nucleic acid-based therapeutics such as RNAi therapies endows them with a significant advantage over other antiviral medications. For example, small interfering RNAs (siRNAs) are produced on the basis of sequence complementarity to target and degrade viral RNA, a novel approach to combat viral infections. The precision of siRNAs in targeting and degrading viral RNA has led to the development of siRNA-based treatments for diverse diseases. However, despite the promising therapeutic benefits of siRNAs, several problems, including impaired long-term protein expression, siRNA instability, off-target effects, immunological responses, and drug resistance, have been considerable obstacles to the use of siRNA-based antiviral therapies. This review provides an encompassing summary of the siRNA-based therapeutic approaches against viruses while also addressing the obstacles that need to be overcome for their effective application. Furthermore, we present potential solutions to mitigate major challenges.

논문정보

형식Review Paper
게재일2023년 10월 (BRIC 등록일 2023-10-24)
연구진국내 연구진
분야 생명과학 > 미생물학

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