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Nat. Mater., Oct 16 2023, | https://doi.org/10.1038/s41563-023-01688-w Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

Whee-Soo Kim ^1,2,3,11, Sungjin Min ^4,11, Su Kyeom Kim ⁴, Sunghwi Kang ^1,3,5, Soohwan An ⁴, Ernesto Criado-Hidalgo ², Hunter Davis ², Avinoam Bar-Zion ², Dina Malounda ², Yu Heun Kim ⁴, Jae-Hyun Lee ^1,3, Soo Han Bae ^6,7, Jin Gu Lee ⁸, Minsuk Kwak ^1,3, Seung-Woo Cho ^1,3,4,*, Mikhail G. Shapiro ^1,2,3,9,10,* & Jinwoo Cheon ^1,3,5,*

¹Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea.
²Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
³Department of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul, Republic of Korea.
⁴Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.
⁵Department of Chemistry, Yonsei University, Seoul, Republic of Korea.
⁶Severance Biomedical Science Institute, Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
⁷Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
⁸Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
⁹Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
¹⁰Howard Hughes Medical Institute, Pasadena, CA, USA.
¹¹These authors contributed equally: Whee-Soo Kim, Sungjin Min.

^*Corresponding authors: correspondence to Seung-Woo Cho, Mikhail G. Shapiro or Jinwoo Cheon

Abstract

Measuring cellular and tissue mechanics inside intact living organisms is essential for interrogating the roles of force in physiological and disease processes. Current agents for studying the mechanobiology of intact, living organisms are limited by poor light penetration and material stability. Magnetomotive ultrasound is an emerging modality for real-time in vivo imaging of tissue mechanics. Nonetheless, it has poor sensitivity and spatiotemporal resolution. Here we describe magneto-gas vesicles (MGVs), protein nanostructures based on gas vesicles and magnetic nanoparticles that produce differential ultrasound signals in response to varying mechanical properties of surrounding tissues. These hybrid nanomaterials significantly improve signal strength and detection sensitivity. Furthermore, MGVs enable non-invasive, long-term and quantitative measurements of mechanical properties within three-dimensional tissues and in vivo fibrosis models. Using MGVs as novel contrast agents, we demonstrate their potential for non-invasive imaging of tissue elasticity, offering insights into mechanobiology and its application to disease diagnosis and treatment.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-10-18)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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