Ahmed Fuwad (인하대학교) | 한빛사논문 > 한빛사

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조회422

Ahmed FuwadAhmed Fuwad

인하대학교

Nano Lett., Oct 16 2023, | https://doi.org/10.1021/acs.nanolett.3c02936 Elucidating the Molecular Interactions between Lipids and Lysozyme: Evaporation Resistance and Bacterial Barriers for Dry Eye Disease

Deborah Lee ^1,2, Seoyoon Song ^1,2, Geonho Cho¹, Lucia C Dalle Ore ², Noah Malmstadt ², Ahmed Fuwad³, Sun Min Kim ^1,3, Tae-Joon Jeon ^1,4

¹Department of Biological Sciences and Bioengineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.

²Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, United States.

³Department of Mechanical Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.

⁴Department of Biological Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea.

Corresponding Authors : Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon

Abstract

Dry eye disease (DED) is a chronic condition characterized by ocular dryness and inflammation. The tear film lipid layer (TFLL) is the outermost layer composed of lipids and proteins that protect the ocular surface. However, environmental contaminants can disrupt its structure, potentially leading to DED. Although the importance of tear proteins in the TFLL functionality has been clinically recognized, the molecular mechanisms underlying TFLL-protein interactions remain unclear. In this study, we investigated tear protein-lipid interactions and analyzed their role in the TFLL functionality. The results show that lysozyme (LYZ) increases the stability of the TFLL by reducing its surface tension and increasing its surface pressure, resulting in increased TFLL evaporation and bacterial invasion resistance, with improved wettability and lubrication performance. These findings highlight the critical role of LYZ in maintaining ocular health and provide potential avenues for investigating novel approaches to DED treatment and patient well-being.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-10-17)
연구진국내 연구진
분야 바이오·의료융합 > 바이오·의료융합 기타

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