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J. Hazard. Mater., Oct 12 2023, 462 S0304-3894(23)02047-2 | https://doi.org/10.1016/j.jhazmat.2023.132763 Modified toxic potential of multi-walled carbon nanotubes to zebrafish (Danio rerio) following a two-year incubation in water

Youn-Joo Jung ^a,b,1, Thillaichidambaram Muneeswaran ^c,1, Jin Soo Choi ^a,b, Sumin Kim ^d, Jong Hun Han ^d, Wan-Seob Cho ^c, June-Woo Park^a,b,e

^aEnvironmental Exposure & Toxicology Research Center, Korea Institute of Toxicology, Jinju 52834, Republic of Korea

^bJoint Research Center for Alternative and Predictive Toxicology (JRC-APT), Korea Institute of Toxicology, Jinju 52834, Republic of Korea

^cLab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Republic of Korea

^dSchool of Applied Chemical Engineering, Chonnam National University, Gwangju 61186, Republic of Korea

^eHuman and Environmental Toxicology Program, Korea University of Science and Technology (UST), Daejeon 34113, Republic of Korea

¹These authors contributed equally to this work.

Corresponding authors: Wan-Seob Cho, June-Woo Park

Abstract

Multi-walled carbon nanotubes (MWCNTs), widely used in several industrial fields, are not readily degradable thus, persist in environmental matrices, serving as a source of environmental toxicity to organisms. However, the effects of environmental weathering on nanomaterial toxicity remain unclear. Herein, we prepared aged-MWCNTs (a-CNTs) by incubating commercial pristine-MWCNTs (p-CNTs) for two years and compared their changes in physicochemical properties and toxic effects on zebrafish. The characterization of a-CNTs by transmission electron microscopy, X-ray photoelectron spectra, Raman spectroscopy, and Fourier-transform infrared spectroscopy showed an increased surface area, pore size, structural defects, and surface oxidation than those of p-CNTs. Zebrafish were exposed to 100 mg/L p-CNT and a-CNT for four days. Subsequently, the mRNA expression of antioxidant enzymes, including cat, gst, and sod, in a-CNT group increased by 1.5- to 1.7-fold, consistent with increased expression of genes associated with inflammation (interleukin-8) and apoptosis (p53) compared to control. The higher toxicity of a-CNTs to zebrafish than p-CNT might be due to the increased oxidative potential by altered physicochemical properties. These findings provide new insights into the risk assessment and environmental management of MWCNTs in the aquatic environment. However, further testing at environmentally relevant doses, different exposure durations, and diverse weathering parameters is warranted.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-10-17)
연구진국내 연구진
분야 의약학 > 응용의학

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