안동준 (고려대학교, 화공생명공학과)

한빛사논문

조회304

고려대학교, 화공생명공학과

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Nano Lett., Oct 16 2023, | https://doi.org/10.1021/acs.nanolett.3c03059 Self-Assembled Nanostructures of Homo-Oligopeptide as a Potent Ice Growth Inhibitor

Yong Duk Kim ¹, Woo Hyuk Jung ², Dong June Ahn ^1,2, Dong-Kwon Lim^1,3,4

¹KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

²Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

³Department of Integrative Energy Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

⁴Brain Science Institute, Korea Institute of Science and Technology (KIST), 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.

Y.D.K. and W.H.J. contributed equally to this manuscript.

Corresponding Authors : Dong June Ahn, Dong-Kwon Lim

Abstract

This study reports the formation of self-assembled nanostructures with homo-oligopeptides consisting of amino acids (i.e., alanine, threonine, valine, and tyrosine), the resulting morphologies (i.e., spherical shape, layered structure, and wire structure) in aqueous solution, and their potential as ice growth inhibitors. Among the homo-oligopeptides investigated, an alanine homo-oligopeptide ( n = 5) with a spherical nanostructure showed the highest ice recrystallization inhibition (IRI) activity without showing a burst ice growth property and with low ice nucleation activity. The presence of nanoscale self-assembled structures in the solution showed superior IRI activity compared to an amino acid monomer because of the higher binding affinity of structures on the growing ice crystal plane. Simulation results revealed that the presence of nanostructures induced a significant inhibition of ice growth and increased lifetime of hydrogen bonding compared with unassembled homo-oligopeptide. These results envision extraordinary performance for self-assembled nanostructures as a desirable and potent ice growth inhibitor.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-10-17)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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