한빛사논문
- 조회419
Ju Hee Kim1, Eun Lee2, Eun Kyo Ha3, Jeewon Shin4, Gi Chun Lee5, Yeong Ho Rha1, Man Yong Han4
1Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea
2Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
3Department of Pediatrics, Kangnam Sacred Heart Hospital, Seoul, Korea
4Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Korea
5Department of Computer Science and Engineering, Konkuk University, Seoul, Korea
Ju Hee Kim and Eun Lee contributed equally to this study as cofirst authors.
CORRESPONDING AUTHOR : Man Yong Han
Abstract
Background: Individuals with atopic dermatitis often develop other conditions.
Objective: This study aimed to determine how atopic dermatitis comorbidities develop in children over time.
Methods: This population-based administrative cohort study used national health insurance data. We traced individuals born in Korea between 2002 and 2003 to 2018. The date of initial atopic dermatitis diagnosis was set as the index date. Fifty-three childhood comorbidities of atopic dermatitis were identified as outcomes of interest by performing a comprehensive literature search and comparing the prevalence of diagnostic codes in children with and without atopic dermatitis. Four control children per individual in the atopic dermatitis group were randomly matched based on sex and index date. The association between atopic dermatitis and the development of each specified disease was assessed using proportional hazard assumption, followed by mapping of the temporal sequences of interconnected comorbidities.
Results: The atopic dermatitis and control groups contained 67,632 and 270,528 individuals, respectively. The median age at the index date was 10 months, whereas the median follow-up period was 15 years. Twenty diseases that were associated with a higher risk of atopic dermatitis were identified and a chain of interconnected conditions created. The progression began in childhood with febrile seizures, constipation, and asthma, and was later associated with the emergence of food allergy, allergic rhinitis, psychiatric disorders, and autoimmune diseases.
Conclusion: Our study highlights the temporal nature of atopic dermatitis comorbidities in children, and indicates that an understanding of the comorbidities may inform its clinical management and treatment.
논문정보
- Research article
- 2023년 10월 (BRIC 등록일 2023-10-17)
- 국내 연구진
- 의약학 > 응용의학
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