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Carbohydr. Polym., 2 September 2023 | https://doi.org/10.1016/j.carbpol.2023.121341 Retrograded octenylsuccinylated maize starch-based emulgels for a promising oral delivery system of curcumin

Myeongsu Jo ^a,1, Sung Hyun Kim ^b,1, Ha Eun Kim ^c, You Young Lee ^c, Eunghee Kim ^f, Choongjin Ban ^d, Young Jin Choi ^a,c,e

^aCenter for Food and Bioconvergence, Seoul National University, Gwanakgu, Seoul 08826, Republic of Korea

^bBinggrae Co. Ltd., Namyangjusi, Gyeonggido 12253, Republic of Korea

^cDepartment of Agricultural Biotechnology, Seoul National University, Gwanakgu, Seoul 08826, Republic of Korea

^dDepartment of Environmental Horticulture, University of Seoul, Dongdaemungu, Seoul 02504, Republic of Korea

^eResearch Institute of Agriculture and Life Sciences, Seoul National University, Gwanakgu, Seoul 08826, Republic of Korea

^fSmart Food Manufacturing Project Group, Korea Food Research Institute, Wanju 55365, Republic of Korea

¹These authors contributed equally to this work.

Corresponding authors: Choongjin Ban, Young Jin Choi

Abstract

Emulgels are a type of soft solid delivery system that exploit the merits of both emulsions and gels, namely, bioactive encapsulability and structural stability, respectively. We utilized retrograded/octenylsuccinylated maize starch (ROMS) to fabricate the curcumin-loaded emulgel. Emulgels (oil volume fraction, 0.20) prepared with 1-4 % w/w ROMS exhibited fluid-like behaviors while emulgels with 5-8 % w/w ROMS exhibited a gel-like consistency. Compared to a fluidic emulsion stabilized with 3 % w/w octenylsuccinylated maize starch, the emulgels showed more sustained lipolysis and controlled curcumin release patterns. These results were attributed to rigid ROMS structures at the outer layer of oil droplets, hindering the lipase approach onto the oil/water interface and curcumin diffusion from the interface. Additionally, the bioaccessibility of curcumin in ROMS-stabilized emulgels was enhanced >9.6-fold compared to that of a curcumin solution. Furthermore, emulgels prepared with 8 % w/w ROMS exhibited a high yield stress (376.4 Pa) and maintained appearance and droplet size for 60 days of storage at 4 °C. Consequently, this emulgel has potential as a lipophilic bioactive-containing soft gel with sustained digestion and controlled release properties. Our findings may provide insights into rational delivery system designs.

논문정보

형식Research article
게재일2023년 09월 (BRIC 등록일 2023-10-24)
연구진국내 연구진
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