Hoa Thi Quynh Le (경희대학교) | 한빛사논문 > 한빛사

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Hoa Thi Quynh LeHoa Thi Quynh Le

경희대학교

Bioresour. Technol., Sep 2023, 384 S0960-8524(23)00722-8 | https://doi.org/10.1016/j.biortech.2023.129296 Methanotrophs: Metabolic versatility from utilization of methane to multi-carbon sources and perspectives on current and future applications.

Hoa Thi Quynh Le, Eun Yeol Lee

Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin 17104, Republic of Korea

Corresponding author : Eun Yeol Lee

Abstract

The development of biorefineries for a sustainable bioeconomy has been driven by the concept of utilizing environmentally friendly and cost-effective renewable energy sources. Methanotrophic bacteria with a unique capacity to utilize methane as a carbon and energy source can serve as outstanding biocatalysts to develop C1 bioconversion technology. By establishing the utilization of diverse multi-carbon sources, integrated biorefinery platforms can be created for the concept of the circular bioeconomy. An understanding of physiology and metabolism could help to overcome challenges for biomanufacturing. This review summaries fundamental gaps for methane oxidation and the capability to utilize multi-carbon sources in methanotrophic bacteria. Subsequently, breakthroughs in harnessing methanotrophs as robust microbial chassis for industrial biotechnology were compiled and overviewed. Finally, challenges and capabilities to exploit the inherent advantages of methanotrophs to synthesize various target products in higher titers are proposed.

논문정보

형식Review Paper
게재일2023년 09월 (BRIC 등록일 2023-10-13)
연구진국내 연구진
분야 생명과학 > 생물공학

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