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한빛사논문
- 조회389
Nat. Nanotechnol., Aug 2023, 18 (8) | https://doi.org/10.1038/s41565-023-01381-8
Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery.
Min-Jun Baek 1, Duy-Thuc Nguyen 1, Dahan Kim 1, So-Yeol Yoo 2, Sang Min Lee 2, Jae-Young Lee 2 & Dae-Duk Kim 1
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
2College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Corresponding authors : Correspondence to Jae-Young Lee or Dae-Duk Kim.
Abstract
Although cyclodextrin-based renal-clearable nanocarriers have a high potential for clinical translation in targeted cancer therapy, their designs remain to be optimized for tumour retention. Here we report on the design of a tailored structure for renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery. Twenty cyclodextrin derivatives with different charged moieties and spacers are synthesized and screened for colloidal stability. The resulting five candidates are evaluated for biodistribution and an optimized structure is identified. The optimized cyclodextrin shows a high tumour accumulation and is used for delivery of doxorubicin and ulixertinib. Higher tumour accumulation and tumour penetration facilitates tumour elimination. The improved antitumour efficacy is demonstrated in heterotopic and orthotopic colorectal cancer models.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-10-11)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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