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조회405

김수연Sooyeon Kim

전북대학교

J. Control. Release, Oct 03 2023, S0168-3659(23)00654-5 | https://doi.org/10.1016/j.jconrel.2023.10.004 Targeted echogenic and anti-inflammatory polymeric prodrug nanoparticles for the management of renal ischemia/reperfusion injury.

Sooyeon Kim ^a, Hanui Jo ^a, Suyeon Lee ^a, Manseok Yang ^a, Hayoung Jun ^a, Youngjong Lee ^a, Gi-Wook Kim ^a,b, Dongwon Lee ^a,c

^aDepartment of Nanobiotechnology and Bioconvergence Engineering, Jeonbuk National University, Jeonju, Jeonbuk 54896, Republic of Korea

^bDepartment of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School, Jeonju, Jeonbuk 54097, Republic of Korea

^cDepartment of Polymer⋅Nano Science and Technology, Jeonbuk National University, Jeonju, Jeonbuk 54896, Republic of Korea

Corresponding authors : Gi-Wook Kim, Dongwon Lee

Abstract

Ischemia/reperfusion (IR) injury is an inevitable pathological event occurring when blood is resupplied to the tissues after a period of ischemia. One of major causes of IR injury is the overproduction of reactive oxygen species (ROS) including hydrogen peroxide (H ₂O ₂), which mediates the expression of various inflammatory cytokines to exacerbate tissue damages. The overproduced H ₂O ₂ could therefore serve as a diagnostic and therapeutic biomarker of IR injury. In this study, poly(boronated methacrylate) (pBMA) nanoparticles were developed as nanotheranostic agents for renal IR injury, which not only generate CO ₂ bubbles to enhance the ultrasound contrast but also provide potent preventive effects in a H ₂O ₂-triggered manner. The surface of pBMA nanoparticles was decorated with taurodeoxycholic acid (TUDCA) that binds P-selectin overexpressed in inflamed tissues. In the mouse model of renal IR injury, TUDCA-coated pBMA (T-pBMA) nanoparticles preferentially accumulated in the injured kidney and markedly enhanced the ultrasound contrast. T-pBMA nanoparticles also effectively prevented renal IR injury by scavenging H ₂O ₂ and suppressing the expression of inflammatory cytokines. Treatment progress of IR injury could be also monitored by echogenic T-pBMA nanoparticles. Given their targeting ability, excellent H ₂O ₂-responsiveness, anti-inflammatory activity and H ₂O ₂-triggered echogenicity, T-pBMA nanoparticles have excellent translational potential for the management of various H ₂O ₂-related diseases including IR injury.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-10-18)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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