Phuong Le Tran (영남대학교)

한빛사논문

조회328

Phuong Le TranPhuong Le Tran

영남대학교

J. Control. Release, Available online 25 October 2023 | https://doi.org/10.1016/j.jconrel.2023.10.008 Magnetic resonance imaging of pancreatic islets using tissue–adhesive particles containing iron oxide nanoparticles

Phuong Le Tran ^a, Tung Thanh Pham ^a, Han Sin Lee ^b, Soojung Hahn ^c, Jeong Uk Choi ^d, Jae Hyeon Kim ^e,f, Hu-Lin Jiang ^g,h,i,j, Simmyung Yook ^k,l,m, Jee-Heon Jeong ^a,n

^aCollege of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea

^bR&D Center, Cellstormer, Suwon, Gyeonggi 16677, Republic of Korea

^cSamsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06355, Republic of Korea

^dCollege of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea

^eDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

^fDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

^gState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China

^hJiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China

ⁱJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China

^jJiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China

^kCollege of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea

^lSchool of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea

^mDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea

ⁿDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea

Correspondence to: S. Yook, J.-H. Jeong

Abstract

Post-transplantation tracking of pancreatic islets is a prerequisite for advancing cell therapy to treat type 1 diabetes. Magnetic resonance imaging (MRI) has emerged as a safe and non-invasive technique for visualizing cells in clinical applications. In this study, we proposed a novel MRI contrast agent formulation by encapsulating iron oxide nanoparticles (IONPs) in poly(lactic-co-glycolic acid) (PLGA) particles functionalized with a tissue adhesive polydopamine (PD) layer (IONP-PLGA-PD MS). Intriguingly, our particles facilitated efficient and robust labeling through a one-step process, allowing for the incorporation of a substantial amount of IONPs without detrimental impacts on the viability and functionality of pancreatic islets. The MRI signals emanating from islets labeled using our particles were found to be stable over 30 days in vitro and 60 days when transplanted under kidney capsules of diabetic mice. These results suggest that our approach provides a potential platform for monitoring the fate of pancreatic islets after transplantation.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-10-26)
연구진국내(교신)+국외 연구진
분야 의약학 > 약학

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