황석원 (고려대학교)

한빛사논문

조회421

고려대학교

CV File 318 kb

Adv. Mater., Sep 28 2023 | https://doi.org/10.1002/adma.202307391 Soft, Long-Lived, Bioresorbable Electronic Surgical Mesh with Wireless Pressure Monitor and On-demand Drug Delivery.

Rajaram Kaveti ¹, Joong Hoon Lee ^1,2, Joong Kee Youn ³, Tae-Min Jang¹, Won Bae Han ¹, Seung Min Yang ^1,4, Jeong-Woong Shin ¹, Gwan-Jin Ko¹, Dong-Je Kim¹, Sungkeun Han¹, Heeseok Kang ¹, Amay J Bandodkar ^5,6, Hyun-Young Kim ³, Suk-Won Hwang ^1,7,8

¹KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

²SK Hynix Co., Ltd., 2091, Gyeongchung-daero, Bubal-eup, Incheon, Gyeonggi-do, 17336, Republic of Korea.

³Department of Pediatric Surgery, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

⁴Hanwha Systems Co., Ltd., 188, Pangyoyeok-Ro, Bundang-Gu, Seongnam-si, Gyeonggi-do, 13524, Republic of Korea.

⁵Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina, 27606, USA.

⁶Center for Advanced Self-Powered Systems of Integrated Sensors and Technologies (ASSIST), North Carolina State University, Raleigh, North Carolina, 27606, USA.

⁷Department of Integrative Energy Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

⁸Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.

R.K., J.H.L., and J.K.Y. contributed equally to this work.

CORRESPONDING AUTHORS : Hyun-Young Kim, Suk-Won Hwang

Abstract

Current research in the area of surgical mesh implants is somewhat limited to traditional designs and synthesis of various mesh materials, whereas meshes with multiple functions may be an effective approach to address long-standing challenges including postoperative complications. We herein present a bioresorbable electronic surgical mesh that offers high mechanical strength over extended timeframes, wireless post-operative pressure monitoring, and on-demand drug delivery for the restoration of tissue structure and function. Study of materials and mesh layouts provides a wide range of tunability of mechanical, biochemical properties. Dissolvable dielectric composite with porous structure in a pyramidal shape enhances sensitivity of a wireless capacitive pressure sensor, and resistive microheaters integrated with inductive coils provide thermo-responsive drug delivery system for an antibacterial agent. In vivo evaluations demonstrate reliable, long-lived operation and effective treatment for abdominal hernia defects, by clear evidence of suppressed complications such as adhesion formation and infections. This article is protected by copyright. All rights reserved.

논문정보

형식Research article
게재일2023년 09월 (BRIC 등록일 2023-10-06)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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