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- 조회339
송요한Yo Han Song
GIST
Adv. Colloid Interface Sci., Volume 320, October 2023, 103008 | https://doi.org/10.1016/j.cis.2023.103008
Emerging strategies to fabricate polymeric nanocarriers for enhanced drug delivery across blood-brain barrier: An overview.
Yo Han Song a, Ranjit De b,a, Kang Taek Lee a
aDepartment of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea
bDepartment of Material Science and Engineering, Pohang University of Science and Technology, Pohang 37673, South Korea
Corresponding authors: Ranjit De, Kang Taek Lee
Abstract
Blood-brain barrier (BBB) serves as an essential interface between central nervous system (CNS) and its periphery, allowing selective permeation of ions, gaseous molecules, and other nutrients to maintain metabolic functions of brain. Concurrently, it restricts passage of unsolicited materials from bloodstream to CNS which could otherwise lead to neurotoxicity. Nevertheless, in the treatment of neurodegenerative diseases such as Parkinson's, Alzheimer's, diffuse intrinsic pontine glioma, and other brain cancers, drugs must reach CNS. Among various materials developed for this purpose, a few judiciously selected polymeric nanocarriers are reported to be highly prospective to facilitate BBB permeation. However, the challenge of transporting drug-loaded nanomaterials across this barrier remains formidable. Herein a concise analysis of recently employed strategies for designing polymeric nanocarriers to deliver therapeutics across BBB is presented. Impacts of 3Ss, namely, size, shape, and surface charge of polymeric nanocarriers on BBB permeation along with different ligands used for nanoparticle surface modification to achieve targeted delivery have been scrutinized. Finally, we elucidated future research directions in the context of designing smart polymeric nanocarriers for BBB permeation. This work aims to guide researchers engaged in polymeric nanocarrier design, helping them navigate where to begin, what challenges to address, and how to proceed effectively.
논문정보
- Review Paper
- 2023년 10월 (BRIC 등록일 2023-10-17)
- 국내 연구진
관련 보도자료
신경계 퇴행성 질환 치료 위한 고분자 나노운반체 개발
국내 연구진이 신경계 퇴행성 질환 치료제의 체내 투과 효율을 증가시킬 수 있는 나노운반체 기술을 개발했다. 이번 연구 성과는 체내 약물 투과 효율을 높여 해당 질병의 치료제 개발에 새로운 방향성을 제시할 뿐 아니라 고분자 나노운반체 연구 개발에도 매우 중요한 정보를 제공할 것으로 기대된다. 광주과학기술원(GIST, 총장 임기철) 화학과 이강택 교수팀은 포항공과대학교(POSTECH) 데 란짓(Ranjit De) 연구부교수 연구팀과 공동으로 약물 전달 시스템과 알츠하이머병, 파킨슨병 등과 같은 퇴행성 신경 질환을 모니터링하기 위한 나노입자 기반 치료제 모델을 연구해 왔다.
- Bio통신원
- 2023. 10. 17
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