한빛사논문
- 조회299
Yue Huang 1,2,3,15, Yuan Liu 2,4,15, Nil Kanatha Pandey 1,2,3,15, Shrey Shah 1,5, Aurea Simon-Soro 2,3,6, Jessica C. Hsu 1,5, Zhi Ren 2,3,7, Zhenting Xiang 2,3, Dongyeop Kim 2,3,8, Tatsuro Ito 2,3,9, Min Jun Oh 2,3,10, Christine Buckley 11, Faizan Alawi 12, Yong Li 2,3, Paul J. M. Smeets 13,14, Sarah Boyer 14, Xingchen Zhao 14, Derk Joester 14, Domenick T. Zero 11, David P. Cormode 1,5,* & Hyun Koo 2,3,7,*
1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
2Biofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
3Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
4Department of Preventive and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
5Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
6Department of Stomatology, Dental School, University of Seville, Seville, Spain.
7Center for Innovation and Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
8Department of Preventive Dentistry, School of Dentistry, Jeonbuk National University, Jeonju, Republic of Korea.
9Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
10Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.
11Department of Cariology, Operative Dentistry and Dental Public Health and Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.
12Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
13Northwestern University Atomic and Nanoscale Characterization Experimental Center, Northwestern University, Evanston, IL, USA.
14Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
15These authors contributed equally: Yue Huang, Yuan Liu, Nil Kanatha Pandey.
*Corresponding authors: correspondence to David P. Cormode or Hyun Koo
Abstract
Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when Fer is combined with stannous fluoride (SnF2), markedly inhibiting both biofilm accumulation and enamel damage more effectively than either alone. Unexpectedly, we discover that the stability of SnF2 is enhanced when mixed with Fer in aqueous solutions while increasing catalytic activity of Fer without any additives. Notably, Fer in combination with SnF2 is exceptionally effective in controlling dental caries in vivo, even at four times lower concentrations, without adverse effects on host tissues or oral microbiome. Our results reveal a potent therapeutic synergism using approved agents while providing facile SnF2 stabilization, to prevent a widespread oral disease with reduced fluoride exposure.
논문정보
- Research article
- 2023년 09월 (BRIC 등록일 2023-10-26)
- 국내+국외 연구진
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