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한국생명공학연구원

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Exp. Mol. Med., 02 October 2023 | https://doi.org/10.1038/s12276-023-01094-x Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease

Eun-Young Lee ¹, Jungwon Hwang ¹ and Myung Hee Kim ^1,*

¹Microbiome Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.

^*Corresponding author: correspondence to Myung Hee Kim

Abstract

Ubiquitously expressed aminoacyl-tRNA synthetases play essential roles in decoding genetic information required for protein synthesis in every living species. Growing evidence suggests that they also function as crossover mediators of multiple biological processes required for homeostasis. In humans, eight cytoplasmic tRNA synthetases form a central machinery called the multi-tRNA synthetase complex (MSC). The formation of MSCs appears to be essential for life, although the role of MSCs remains unclear. Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is the most evolutionarily derived component within the MSC that plays a critical role in immunity and metabolism (beyond its catalytic role in translation) via stimulus-dependent phosphorylation events. This review focuses on the role of EPRS1 signaling in inflammation resolution and metabolic modulation. The involvement of EPRS1 in diseases such as cancer is also discussed.

논문정보

형식Review Paper
게재일2023년 10월 (BRIC 등록일 2023-10-04)
연구진국내 연구진
분야 생명과학 > 생화학

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