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한빛사논문
- 조회664
Exp. Mol. Med., Oct 02 2023 | https://doi.org/10.1038/s12276-023-01086-x
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics.
Yeji Lee1, Michaela Jeong1, Jeongeun Park1, Hyein Jung1 and Hyukjin Lee1
1College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, South Korea.
Corresponding author : Correspondence to Hyukjin Lee.
Abstract
Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles.
논문정보
- Review Paper
- 2023년 10월 (BRIC 등록일 2023-10-04)
- 국내 연구진
- 의약학 > 약학
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