한빛사논문
Solhwi Lee # 1, Kunhee Lee # 1, Hyeonjin Bae 1, Kyungmin Lee 1, Junghwa Lee 2, Junhui Ma 1, Ye Ji Lee 3, Bo Ryeong Lee 3, Woong-Yang Park 3 4, Se Jin Im 5 *
1Department of Immunology, Graduate School of Basic Medical Science, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
2Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
3GENINUS Inc., Seoul, Republic of Korea.
4Samsung Genome Institute, Samsung Medical Center, Seoul, Republic of Korea.
5Department of Immunology, Graduate School of Basic Medical Science, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
#Contributed equally.
*Corresponding author: correspondence to Se Jin Im
Abstract
Graft-versus-host disease (GvHD) is a severe complication of hematopoietic stem cell transplantation driven by activated allogeneic T cells. Here, we identify a distinct subset of T cell factor-1 (TCF1)+ CD8+ T cells in mouse allogeneic and xenogeneic transplant models of acute GvHD. These TCF1+ cells exhibit distinct characteristics compared to TCF1- cells, including lower expression of inhibitory receptors and higher expression of costimulatory molecules. Notably, the TCF1+ subset displays exclusive proliferative potential and could differentiate into TCF1- effector cells upon antigenic stimulation. Pathway analyses support the role of TCF1+ and TCF1- subsets as resource cells and effector cells, respectively. Furthermore, the TCF1+ CD8+ T cell subset is primarily present in the spleen and exhibits a resident phenotype. These findings provide insight into the differentiation of allogeneic and xenogeneic CD8+ T cells and have implications for the development of immunotherapeutic strategies targeting acute GvHD.
논문정보
관련 링크
연구자 키워드
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기