한빛사논문
- 조회295
Jinhyeong Jang a,b, Calvin Andreas Hutomo a, Chan Beum Park a
aDepartment of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 34141, Republic of Korea
bApplied Science Research Institute, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 34141, Republic of Korea
Corresponding author: Chan Beum Park
Abstract
Magnetic field-boosted electrochemistry has recently emerged as an effective strategy to enhancing the catalytic capability in industrially profitable purposes. However, its utilization to enhance the quality of life of individuals has not been thoroughly investigated yet. Here, we have unveiled a static magnetic field-boosted electrocatalytic process for the dissociation of self-assembled β-amyloid (Aβ) aggregates, the major pathological hallmark of Alzheimer’s disease (AD). Cobalt-doped titanium oxide (Co-TiO2) electrode exhibits the repetitive boosting and recovery of electrical current density in response to an applied static magnetic field due to ferromagnetic cobalt dopants. According to our microscopic and spectroscopic analyses results, Co-TiO2 electrode successfully triggers the dissociation process of Aβ aggregate structure only with applied voltage. Besides, the dissociation efficacy of Co-TiO2 electrode against Aβ aggregates is boosted when a static magnetic field is applied in addition to the voltage. Our in vitro evaluation results demonstrate that Co-TiO2 electrode has biocompatibility and mitigating effect against Aβ-associated neurotoxicity. Also, our ex vivo evaluation results confirm that Co-TiO2 electrode can clear micrometer-sized and accumulated Aβ aggregates from AD mouse brain tissue. This work discovers a therapeutic potential of static magnetic field-boosted bioelectrocatalysis for future AD treatment.
논문정보
- Research article
- 2023년 09월 (BRIC 등록일 2023-09-26)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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