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조회433

건국대학교

Carbohydr. Polym., Available online 11 August 2023 | https://doi.org/10.1016/j.carbpol.2023.121287 Development of cultivable alginate fibers for an ideal cell-cultivated meat scaffold and production of hybrid cultured meat.

Jeong Wook Seo ^a,b, Woo Kyung Jung ^b, Yong Ho Park^b,c, Hojae Bae^a,d

^aDepartment of Stem Cell and Regenerative Biotechnology, KU Convergence Science and Technology Institute, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea

^bNoAH Biotech Co., Ltd., Suwon-si, Gyeonggi-do 16614, Republic of Korea

^cDepartment of Microbiology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

^dInstitute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea

Corresponding author : Hojae Bae

Abstract

Slaughtering animals for meat pose several challenges, including environmental pollution and ethical concerns. Scaffold-based cell-cultivated meat has been proposed as a solution to these problems, however, the utilization of animal-derived materials for scaffolding or the high cost of production remains a significant challenge. Alginate is an ideal material for cell-cultivated meat scaffolds but has poor cell adhesion properties. To address this issue, we achieved 82 % cell adhesion coverage by controlling the specific structure generated during the ionic crosslinking process of alginate. Post 11 days of culture; we evaluated cell adhesion, differentiation, and aligned cell networks. The cell growth increased by 12.7 % compared to the initial seeding concentration. Finally, we created hybrid cell-cultivated meat by combining single-cell protein from mycelium and cell-cultivated meat. This is non-animal based, edible, cost-effective, and has a desirable texture by blending cell-cultivated meat with a meat analogue. In summary, the creation of improved alginate fibers can effectively tackle various obstacles encountered in the manufacturing of cell-cultivated meat. This includes enhancing cell adhesion, reducing costs, and streamlining the production procedure.

논문정보

형식Research article
게재일2023년 08월 (BRIC 등록일 2023-10-13)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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