도학원 (Houston Methodist Hospital Research Institute, 극지연구소)

한빛사 논문

조회168

Houston Methodist Hospital Research Institute, 극지연구소

CV File 158 kb

Nat. Commun., Sep 23 2023, 14 (1) | https://doi.org/10.1038/s41467-023-41719-3 The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes.

Shifu Aggarwal^1,2,7, Elaine Huang^1,2,7, Hackwon Do^1,2,3,7, Nishanth Makthal^1,2, Yanyan Li⁴, Eric Bapteste⁵, Philippe Lopez⁵, Charles Bernard⁶ & Muthiah Kumaraswami^1,2

¹Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, TX 77030, USA.

²Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.

³Research Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon 21990, South Korea.

⁴Communication Molecules and Adaptation of Microorganisms (MCAM), CNRS, Muséum National d’Histoire Naturelle, Paris, France.

⁵Institut de Systématique, Evolution et Biodiversité (ISYEB), Sorbonne Université, CNRS, Muséum National d’Histoire Naturelle, Paris, France.

⁶Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.

⁷These authors contributed equally: Shifu Aggarwal, Elaine Huang, Hackwon Do.

These authors contributed equally: Shifu Aggarwal, Elaine Huang, Hackwon Do.

Corresponding authors : Correspondence to Charles Bernard or Muthiah Kumaraswami.

Abstract

The human pathogen Streptococcus pyogenes secretes a short peptide (leaderless communication peptide, LCP) that mediates intercellular communication and controls bacterial virulence through interaction with its receptor, RopB. Here, we show that LCP and RopB homologues are present in other Firmicutes. We experimentally validate that LCPs with distinct peptide communication codes act as bacterial intercellular signals and regulate gene expression in Streptococcus salivarius, Streptococcus porcinus, Enterococcus malodoratus and Limosilactobacillus reuteri. Our results indicate that LCPs are more widespread than previously thought, and their characterization may uncover new signaling mechanisms and roles in coordinating diverse bacterial traits.

논문정보

형식Research article
게재일2023년 09월 (BRIC 등록일 2023-09-25)
연구진국내+국외 연구진
분야 생명과학 > 생화학

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