금창준 (한국과학기술연구원(KIST))

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조회127

한국과학기술연구원(KIST)

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Nano Converg., Sep 11 2023, 10 (1) 42 | https://doi.org/10.1186/s40580-023-00390-6 Biomimetic and bioorthogonal nanozymes for biomedical applications.

Changjoon Keum1†, Cristina‑Maria Hirschbiegel2†, Soham Chakraborty2, Soyeong Jin1,3, Youngdo Jeong1,4,5* and Vincent M. Rotello2*

1Center for Advanced Biomolecular Recognition, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea

2Department of Chemistry, University of Massachusetts, Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

3Department of Chemistry, Hanyang University, Seoul 04763, Republic of Korea

4Department of HY‑KIST Bio‑Convergence, Hanyang University, Seoul 04763, Republic of Korea

5Division of Bio‑Medical Science and Technology, University of Science and Technology, Daejeon 34113, Republic of Korea

†Changjoon Keum and Cristina-Maria Hirschbiegel have contributed equally.

*Correspondence: Youngdo Jeong, Vincent M. Rotello

Abstract

Nanozymes mimic the function of enzymes, which drive essential intracellular chemical reactions that govern biological processes. They efficiently generate or degrade specific biomolecules that can initiate or inhibit biological processes, regulating cellular behaviors. Two approaches for utilizing nanozymes in intracellular chemistry have been reported. Biomimetic catalysis replicates the identical reactions of natural enzymes, and bioorthogonal catalysis enables chemistries inaccessible in cells. Various nanozymes based on nanomaterials and catalytic metals are employed to attain intended specific catalysis in cells either to mimic the enzymatic mechanism and kinetics or expand inaccessible chemistries. Each nanozyme approach has its own intrinsic advantages and limitations, making them complementary for diverse and specific applications. This review summarizes the strategies for intracellular catalysis and applications of biomimetic and bioorthogonal nanozymes, including a discussion of their limitations and future research directions.

논문정보

형식Review Paper
게재일2023년 09월 (BRIC 등록일 2023-09-25)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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