한빛사 논문
- 조회268
Annu. Rev. Med., Sep 20 2023 | https://doi.org/10.1146/annurev-med-051322-120608
Ketamine: Mechanisms and Relevance to Treatment of Depression.
Ji-Woon Kim,1,2,3,4 Kanzo Suzuki,1,5 Ege T. Kavalali,1 and Lisa M. Monteggia1
1Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee,
2College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea
3Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea
4Institute of Regulatory innovation through Science, Kyung Hee University, Seoul, Republic of Korea
5Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, Katsushika-ku, Japan
Corresponding author : Lisa M. Monteggia
Abstract
Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patients highlight the need for improved therapeutic approaches. Over the past two decades, ketamine has shown rapid onset with sustained (up to several days) antidepressant effects in patients whose MDD has not responded to conventional antidepressant drugs. Recent preclinical studies have started to elucidate the underlying mechanisms of ketamine's antidepressant properties. Herein, we describe and compare recent clinical and preclinical findings to provide a broad perspective of the relevant mechanisms for the antidepressant action of ketamine. Expected final online publication date for the
Annual Review of Medicine, Volume 75 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
논문정보
- Review Paper
- 2023년 09월 (BRIC 등록일 2023-09-21)
- 국내+국외 연구진
- 의약학 > 약리의학
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